Metagenomic libraries and natural product discovery platforms

The present disclosure provides methods and systems for identifying multi-gene clusters (MGCs) encoding natural products. In some embodiments, the present disclosure also teaches methods for generating sequenced and assembled metagenomic libraries suitable for MGC search bioinformation tools and tec...

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Hauptverfasser:	GANESH SHRIRAM, SCHOCK, JOACHIM, AYERS, THOMAS, H, HENDRIKS STIJN L. B, SCANNELL DAVID, YANG XIAO, SNEDDEN MICHAEL W, HUANG WAYNE W, KIM JAE HOON, LIU OLIVER, PELIKAN CHRISTIAN, GAMM ULRICH, NECKELMANN ANDREAS, AGUIVA, ERNESTO, OTTEN-PABY SOPHIE, SERBER ZACH
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CALCULATING COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS COMPUTING COUNTING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS PHYSICS
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Zusammenfassung:	The present disclosure provides methods and systems for identifying multi-gene clusters (MGCs) encoding natural products. In some embodiments, the present disclosure also teaches methods for generating sequenced and assembled metagenomic libraries suitable for MGC search bioinformation tools and techniques. 本公开提供了用于鉴定编码天然产物的多基因簇(MGC)的方法和系统。在一些实施例中，本公开还教示了用于产生适于MGC搜索生物信息工具和技术的经测序且经组装的宏基因组文库的方法。