Preparation method of pharmaceutical composition containing sacubitril sodium and valsartan sodium

The invention provides a preparation method of a pharmaceutical composition containing sacubitril sodium and valsartan sodium. The pharmaceutical composition is a double-layer tablet, and the two layers respectively contain sacubitril sodium and valsartan sodium, and simultaneously contain a filler, a disintegrating agent, an adhesive, a lubricant, a stabilizer and a coating material. The existing sacubitril and valsartan sodium eutectic (LCZ696) is easily converted into an amorphous form or decomposed into a single component under a humid and hot condition, so that the safety and the stability of medication are influenced. Through reasonable prescription design, the two main medicines are combined to achieve the same treatment effect, and the technical problem is well solved. 本发明提供了一种含有沙库巴曲钠和缬沙坦钠的药物组合物的制备方法。该药物组合物为双层片，两层中分别含有沙库巴曲钠和缬沙坦钠，同时含有填充剂、崩解剂、粘合剂、润滑剂、稳定剂、包衣材料。现有沙库巴曲缬沙坦钠共晶物(LCZ696)在湿热条件下易转化成无定形或分解成单一成分，影响了用药的安全性与稳定性。本发明通过合理的处方设计使两种主药联用达到相同的治疗效果，很好的解决了这一技术问题。