Method for detecting 4-methylenepiperidine in efinaconazole
The invention belongs to the technical field of chromatographic analysis, and particularly relates to a method for detecting 4-methylenepiperidine in efinaconazole. The invention provides a method for detecting 4-methylenepiperidine in efinaconazole, which comprises the following steps: under the co...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention belongs to the technical field of chromatographic analysis, and particularly relates to a method for detecting 4-methylenepiperidine in efinaconazole. The invention provides a method for detecting 4-methylenepiperidine in efinaconazole, which comprises the following steps: under the condition of a buffer solution, carrying out derivatization reaction on an efinaconazole sample and an FOMC-Cl acetonitrile solution, and then adding a diluent to obtain an efinaconazole derivatization product solution; and detecting the efinaconazole derivatization product solution and the 4-methylenepiperidine solution by adopting high performance liquid chromatography to obtain a qualitative and quantitative detection result of the 4-methylenepiperidine in the efinaconazole sample. A mobile phase passes through a chromatographic column in a gradient elution mode, and then ultraviolet detection is carried out. The invention provides a method for detecting 4-methylenepiperidine in efinaconazole. The method can be us |
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