Method for synthesizing Iguratimod key intermediate
The invention relates to preparation of Iguratimod key intermediate 3-amino-4-phenoxy anisole. The chemical reaction formula of the method is shown in the specification. According to the method, ammonium formate is taken as a hydrogen source, palladium carbon hydroxide is taken as a catalyst, and 3-...
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| creator | LONG XIGUO WANG DONG XU LINYU JIANG HAITING HU KAI LUO PENG QIAO WEN HU GANG |
| description | The invention relates to preparation of Iguratimod key intermediate 3-amino-4-phenoxy anisole. The chemical reaction formula of the method is shown in the specification. According to the method, ammonium formate is taken as a hydrogen source, palladium carbon hydroxide is taken as a catalyst, and 3-nitro-4-phenoxy anisole (2) is reduced into 3-amino-4-phenoxy anisole (1). The structure of the target product is confirmed by HPLC, 1H-NMR, MS and the like. The improved reduction process avoids special hydrogenation pressurization reaction, reduces the safety risk and the production cost, and has high commercial value.
本发明涉及一种艾拉莫德关键中间体3-氨基-4-苯氧基苯甲醚的制备，所述方法的化学反应式如下所示。以甲酸铵作为氢源，氢氧化钯碳为催化剂，将3-硝基-4-苯氧基苯甲醚（2）还原成3-氨基-4-苯氧基苯甲醚（1）。目标产物结构经HPLC、1H-NMR和MS等确证。改进后的还原工艺，避开了氢化加压特种反应，降低了安全风险和生产成本，具有较高的商业化价值。 |
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本发明涉及一种艾拉莫德关键中间体3-氨基-4-苯氧基苯甲醚的制备，所述方法的化学反应式如下所示。以甲酸铵作为氢源，氢氧化钯碳为催化剂，将3-硝基-4-苯氧基苯甲醚（2）还原成3-氨基-4-苯氧基苯甲醚（1）。目标产物结构经HPLC、1H-NMR和MS等确证。改进后的还原工艺，避开了氢化加压特种反应，降低了安全风险和生产成本，具有较高的商业化价值。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221111&DB=EPODOC&CC=CN&NR=115322105A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221111&DB=EPODOC&CC=CN&NR=115322105A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LONG XIGUO</creatorcontrib><creatorcontrib>WANG DONG</creatorcontrib><creatorcontrib>XU LINYU</creatorcontrib><creatorcontrib>JIANG HAITING</creatorcontrib><creatorcontrib>HU KAI</creatorcontrib><creatorcontrib>LUO PENG</creatorcontrib><creatorcontrib>QIAO WEN</creatorcontrib><creatorcontrib>HU GANG</creatorcontrib><title>Method for synthesizing Iguratimod key intermediate</title><description>The invention relates to preparation of Iguratimod key intermediate 3-amino-4-phenoxy anisole. The chemical reaction formula of the method is shown in the specification. According to the method, ammonium formate is taken as a hydrogen source, palladium carbon hydroxide is taken as a catalyst, and 3-nitro-4-phenoxy anisole (2) is reduced into 3-amino-4-phenoxy anisole (1). The structure of the target product is confirmed by HPLC, 1H-NMR, MS and the like. The improved reduction process avoids special hydrogenation pressurization reaction, reduces the safety risk and the production cost, and has high commercial value.
本发明涉及一种艾拉莫德关键中间体3-氨基-4-苯氧基苯甲醚的制备，所述方法的化学反应式如下所示。以甲酸铵作为氢源，氢氧化钯碳为催化剂，将3-硝基-4-苯氧基苯甲醚（2）还原成3-氨基-4-苯氧基苯甲醚（1）。目标产物结构经HPLC、1H-NMR和MS等确证。改进后的还原工艺，避开了氢化加压特种反应，降低了安全风险和生产成本，具有较高的商业化价值。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD2TS3JyE9RSMsvUiiuzCvJSC3OrMrMS1fwTC8tSizJzAXKZadWKmTmlaQW5aamZCaWpPIwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUknhnP0NDU2MjI0MDU0djYtQAADDLLNI</recordid><startdate>20221111</startdate><enddate>20221111</enddate><creator>LONG XIGUO</creator><creator>WANG DONG</creator><creator>XU LINYU</creator><creator>JIANG HAITING</creator><creator>HU KAI</creator><creator>LUO PENG</creator><creator>QIAO WEN</creator><creator>HU GANG</creator><scope>EVB</scope></search><sort><creationdate>20221111</creationdate><title>Method for synthesizing Iguratimod key intermediate</title><author>LONG XIGUO ; WANG DONG ; XU LINYU ; JIANG HAITING ; HU KAI ; LUO PENG ; QIAO WEN ; HU GANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115322105A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LONG XIGUO</creatorcontrib><creatorcontrib>WANG DONG</creatorcontrib><creatorcontrib>XU LINYU</creatorcontrib><creatorcontrib>JIANG HAITING</creatorcontrib><creatorcontrib>HU KAI</creatorcontrib><creatorcontrib>LUO PENG</creatorcontrib><creatorcontrib>QIAO WEN</creatorcontrib><creatorcontrib>HU GANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LONG XIGUO</au><au>WANG DONG</au><au>XU LINYU</au><au>JIANG HAITING</au><au>HU KAI</au><au>LUO PENG</au><au>QIAO WEN</au><au>HU GANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for synthesizing Iguratimod key intermediate</title><date>2022-11-11</date><risdate>2022</risdate><abstract>The invention relates to preparation of Iguratimod key intermediate 3-amino-4-phenoxy anisole. The chemical reaction formula of the method is shown in the specification. According to the method, ammonium formate is taken as a hydrogen source, palladium carbon hydroxide is taken as a catalyst, and 3-nitro-4-phenoxy anisole (2) is reduced into 3-amino-4-phenoxy anisole (1). The structure of the target product is confirmed by HPLC, 1H-NMR, MS and the like. The improved reduction process avoids special hydrogenation pressurization reaction, reduces the safety risk and the production cost, and has high commercial value.
本发明涉及一种艾拉莫德关键中间体3-氨基-4-苯氧基苯甲醚的制备，所述方法的化学反应式如下所示。以甲酸铵作为氢源，氢氧化钯碳为催化剂，将3-硝基-4-苯氧基苯甲醚（2）还原成3-氨基-4-苯氧基苯甲醚（1）。目标产物结构经HPLC、1H-NMR和MS等确证。改进后的还原工艺，避开了氢化加压特种反应，降低了安全风险和生产成本，具有较高的商业化价值。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for synthesizing Iguratimod key intermediate |
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