Method for synthesizing Iguratimod key intermediate

The invention relates to preparation of Iguratimod key intermediate 3-amino-4-phenoxy anisole. The chemical reaction formula of the method is shown in the specification. According to the method, ammonium formate is taken as a hydrogen source, palladium carbon hydroxide is taken as a catalyst, and 3-nitro-4-phenoxy anisole (2) is reduced into 3-amino-4-phenoxy anisole (1). The structure of the target product is confirmed by HPLC, 1H-NMR, MS and the like. The improved reduction process avoids special hydrogenation pressurization reaction, reduces the safety risk and the production cost, and has high commercial value. 本发明涉及一种艾拉莫德关键中间体3-氨基-4-苯氧基苯甲醚的制备，所述方法的化学反应式如下所示。以甲酸铵作为氢源，氢氧化钯碳为催化剂，将3-硝基-4-苯氧基苯甲醚（2）还原成3-氨基-4-苯氧基苯甲醚（1）。目标产物结构经HPLC、1H-NMR和MS等确证。改进后的还原工艺，避开了氢化加压特种反应，降低了安全风险和生产成本，具有较高的商业化价值。