Compositions having thioredoxin activity and related methods

Preparations of proteins or peptides having thioredoxin action when in the reduced state, formulations and their use for the treatment of diseases and/or conditions are disclosed. One aspect of the invention is a method of reducing the viscoelasticity of mucus or sputum in a patient with excessively viscous or sticky mucus or sputum. The method comprises contacting mucus or sputum of a patient with a composition comprising a protein or peptide comprising a thioredoxin monocysteine active site in a reduced state, in which the thioredoxin monocysteine active site has a single Cys in the N-terminal position of the thioredoxin monocysteine active site, in addition to a single Cys in the N-terminal position of the thioredoxin monocysteine active site, a single Cys in the N-terminal position of the thioredoxin monocysteine active site, the protein or peptide does not contain any cysteine residue. 公开了当处于还原状态时具有硫氧还蛋白作用的蛋白质或肽的制备物、制剂和其用于治疗疾病和/或病症用途。本发明的一个方面是一种降低具有过度粘稠或粘着的粘液或痰的患者中粘液或痰的粘弹性的方法。所述方法包括使患者的粘液或痰与包含蛋白质或肽的组合物接触