Double-target sitagliptin derivative

The present invention provides a compound represented by formula (I) and a physiologically acceptable salt thereof, wherein each symbol is as defined in the specification. The compound or the salt thereof has a GPR120 receptor and DPP-IV enzyme dual-function regulation effect after in-vivo metabolis...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LIU RENMIN, WANG MIN, WEI SHITING, LEI KANG, JI LUSHA, WANG XUEKUN, JI GUOXIA, WANG SHIBEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound represented by formula (I) and a physiologically acceptable salt thereof, wherein each symbol is as defined in the specification. The compound or the salt thereof has a GPR120 receptor and DPP-IV enzyme dual-function regulation effect after in-vivo metabolism, on one hand, GLP-1 secretion increase is caused, and on the other hand, GLP-1 is inhibited from being degraded by DPP-IV. Also useful as an insulin secretagogue or a drug for the prevention or treatment of diabetes, metabolic syndrome, diseases related thereto, and the like 本发明提供式(I)表示的化合物及其生理学可接受盐，其中各个符号如说明书中所定义。所述化合物或其盐在体内代谢后具有GPR120受体和DPP-IV酶双重功能调节作用，一方面引起GLP-1分泌增加，另一方面抑制GLP-1被DPP-IV降解。并且作为胰岛素促分泌素或预防或治疗糖尿病、代谢综合征、及其相关疾病等的药物是有用的