Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors
Described herein are compounds that inhibit HIF-2 [alpha] and compositions containing one or more of the compounds and methods of synthesizing the compounds. The use of such compounds and compositions for the treatment of a wide variety of diseases, disorders and conditions, including cancer and imm...
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| creator | JACOB SANDEEP D SU YI MERIAN ABRAHAM K TRAN ANH TUAN LINDSAY ERIC A MANDAL DEBASHIS ROSEN BRAD R WANG ZHULUN MOON HANSEOK POWERS JOHN PATRICK HELLSIG KARL THOMAS GALL BARBARA BEATTIE JAMES W YU KUN GURNEY TIM YAN XINYAN FOURNIER JEROME THOMAS ALAIN HARDMAN CHRISTOPHER EPLING MICHAEL DREW SUSAN L JEFFREY JENNY LYNN LAWSON KATHLEEN VICTORIA KALISIAK JAROSLAW MATTA GUSTAVO RELETI MANMOHAN REDDY |
| description | Described herein are compounds that inhibit HIF-2 [alpha] and compositions containing one or more of the compounds and methods of synthesizing the compounds. The use of such compounds and compositions for the treatment of a wide variety of diseases, disorders and conditions, including cancer and immune related conditions mediated at least in part by HIF-2 [alpha], is also described.
本文描述了抑制HIF-2α的化合物和含有一种或多种所述化合物的组合物以及合成所述化合物的方法。还描述了此类化合物和组合物用于治疗各种各样的疾病、障碍和病症的用途，所述疾病、障碍和病症包括至少部分地由HIF-2α介导的与癌症和免疫有关的病症。 |
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本文描述了抑制HIF-2α的化合物和含有一种或多种所述化合物的组合物以及合成所述化合物的方法。还描述了此类化合物和组合物用于治疗各种各样的疾病、障碍和病症的用途，所述疾病、障碍和病症包括至少部分地由HIF-2α介导的与癌症和免疫有关的病症。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221104&DB=EPODOC&CC=CN&NR=115298165A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221104&DB=EPODOC&CC=CN&NR=115298165A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JACOB SANDEEP D</creatorcontrib><creatorcontrib>SU YI</creatorcontrib><creatorcontrib>MERIAN ABRAHAM K</creatorcontrib><creatorcontrib>TRAN ANH TUAN</creatorcontrib><creatorcontrib>LINDSAY ERIC A</creatorcontrib><creatorcontrib>MANDAL DEBASHIS</creatorcontrib><creatorcontrib>ROSEN BRAD R</creatorcontrib><creatorcontrib>WANG ZHULUN</creatorcontrib><creatorcontrib>MOON HANSEOK</creatorcontrib><creatorcontrib>POWERS JOHN PATRICK</creatorcontrib><creatorcontrib>HELLSIG KARL THOMAS</creatorcontrib><creatorcontrib>GALL BARBARA</creatorcontrib><creatorcontrib>BEATTIE JAMES W</creatorcontrib><creatorcontrib>YU KUN</creatorcontrib><creatorcontrib>GURNEY TIM</creatorcontrib><creatorcontrib>YAN XINYAN</creatorcontrib><creatorcontrib>FOURNIER JEROME THOMAS ALAIN</creatorcontrib><creatorcontrib>HARDMAN CHRISTOPHER</creatorcontrib><creatorcontrib>EPLING MICHAEL</creatorcontrib><creatorcontrib>DREW SUSAN L</creatorcontrib><creatorcontrib>JEFFREY JENNY LYNN</creatorcontrib><creatorcontrib>LAWSON KATHLEEN VICTORIA</creatorcontrib><creatorcontrib>KALISIAK JAROSLAW</creatorcontrib><creatorcontrib>MATTA GUSTAVO</creatorcontrib><creatorcontrib>RELETI MANMOHAN REDDY</creatorcontrib><title>Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors</title><description>Described herein are compounds that inhibit HIF-2 [alpha] and compositions containing one or more of the compounds and methods of synthesizing the compounds. The use of such compounds and compositions for the treatment of a wide variety of diseases, disorders and conditions, including cancer and immune related conditions mediated at least in part by HIF-2 [alpha], is also described.
本文描述了抑制HIF-2α的化合物和含有一种或多种所述化合物的组合物以及合成所述化合物的方法。还描述了此类化合物和组合物用于治疗各种各样的疾病、障碍和病症的用途，所述疾病、障碍和病症包括至少部分地由HIF-2α介导的与癌症和免疫有关的病症。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgOSS0pSsyoTCnKz0ssyCjJSMxJzUtVSMxLUSiByxSWZubl52QCxZPzcwvyS_NSihUSixU8PN10jRSiE3MKMhJjFTLzMjKTMkvyi4p5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFiMtCKknhnP0NDUyNLC0MzU0djYtQAAL5wOPw</recordid><startdate>20221104</startdate><enddate>20221104</enddate><creator>JACOB SANDEEP D</creator><creator>SU YI</creator><creator>MERIAN ABRAHAM K</creator><creator>TRAN ANH TUAN</creator><creator>LINDSAY ERIC A</creator><creator>MANDAL DEBASHIS</creator><creator>ROSEN BRAD R</creator><creator>WANG ZHULUN</creator><creator>MOON HANSEOK</creator><creator>POWERS JOHN PATRICK</creator><creator>HELLSIG KARL THOMAS</creator><creator>GALL BARBARA</creator><creator>BEATTIE JAMES W</creator><creator>YU KUN</creator><creator>GURNEY TIM</creator><creator>YAN XINYAN</creator><creator>FOURNIER JEROME THOMAS ALAIN</creator><creator>HARDMAN CHRISTOPHER</creator><creator>EPLING MICHAEL</creator><creator>DREW SUSAN L</creator><creator>JEFFREY JENNY LYNN</creator><creator>LAWSON KATHLEEN VICTORIA</creator><creator>KALISIAK JAROSLAW</creator><creator>MATTA GUSTAVO</creator><creator>RELETI MANMOHAN REDDY</creator><scope>EVB</scope></search><sort><creationdate>20221104</creationdate><title>Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors</title><author>JACOB SANDEEP D ; SU YI ; MERIAN ABRAHAM K ; TRAN ANH TUAN ; LINDSAY ERIC A ; MANDAL DEBASHIS ; ROSEN BRAD R ; WANG ZHULUN ; MOON HANSEOK ; POWERS JOHN PATRICK ; HELLSIG KARL THOMAS ; GALL BARBARA ; BEATTIE JAMES W ; YU KUN ; GURNEY TIM ; YAN XINYAN ; FOURNIER JEROME THOMAS ALAIN ; HARDMAN CHRISTOPHER ; EPLING MICHAEL ; DREW SUSAN L ; JEFFREY JENNY LYNN ; LAWSON KATHLEEN VICTORIA ; KALISIAK JAROSLAW ; MATTA GUSTAVO ; RELETI MANMOHAN REDDY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115298165A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JACOB SANDEEP D</creatorcontrib><creatorcontrib>SU YI</creatorcontrib><creatorcontrib>MERIAN ABRAHAM K</creatorcontrib><creatorcontrib>TRAN ANH TUAN</creatorcontrib><creatorcontrib>LINDSAY ERIC A</creatorcontrib><creatorcontrib>MANDAL DEBASHIS</creatorcontrib><creatorcontrib>ROSEN BRAD R</creatorcontrib><creatorcontrib>WANG ZHULUN</creatorcontrib><creatorcontrib>MOON HANSEOK</creatorcontrib><creatorcontrib>POWERS JOHN PATRICK</creatorcontrib><creatorcontrib>HELLSIG KARL THOMAS</creatorcontrib><creatorcontrib>GALL BARBARA</creatorcontrib><creatorcontrib>BEATTIE JAMES W</creatorcontrib><creatorcontrib>YU KUN</creatorcontrib><creatorcontrib>GURNEY TIM</creatorcontrib><creatorcontrib>YAN XINYAN</creatorcontrib><creatorcontrib>FOURNIER JEROME THOMAS ALAIN</creatorcontrib><creatorcontrib>HARDMAN CHRISTOPHER</creatorcontrib><creatorcontrib>EPLING MICHAEL</creatorcontrib><creatorcontrib>DREW SUSAN L</creatorcontrib><creatorcontrib>JEFFREY JENNY LYNN</creatorcontrib><creatorcontrib>LAWSON KATHLEEN VICTORIA</creatorcontrib><creatorcontrib>KALISIAK JAROSLAW</creatorcontrib><creatorcontrib>MATTA GUSTAVO</creatorcontrib><creatorcontrib>RELETI MANMOHAN REDDY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JACOB SANDEEP D</au><au>SU YI</au><au>MERIAN ABRAHAM K</au><au>TRAN ANH TUAN</au><au>LINDSAY ERIC A</au><au>MANDAL DEBASHIS</au><au>ROSEN BRAD R</au><au>WANG ZHULUN</au><au>MOON HANSEOK</au><au>POWERS JOHN PATRICK</au><au>HELLSIG KARL THOMAS</au><au>GALL BARBARA</au><au>BEATTIE JAMES W</au><au>YU KUN</au><au>GURNEY TIM</au><au>YAN XINYAN</au><au>FOURNIER JEROME THOMAS ALAIN</au><au>HARDMAN CHRISTOPHER</au><au>EPLING MICHAEL</au><au>DREW SUSAN L</au><au>JEFFREY JENNY LYNN</au><au>LAWSON KATHLEEN VICTORIA</au><au>KALISIAK JAROSLAW</au><au>MATTA GUSTAVO</au><au>RELETI MANMOHAN REDDY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors</title><date>2022-11-04</date><risdate>2022</risdate><abstract>Described herein are compounds that inhibit HIF-2 [alpha] and compositions containing one or more of the compounds and methods of synthesizing the compounds. The use of such compounds and compositions for the treatment of a wide variety of diseases, disorders and conditions, including cancer and immune related conditions mediated at least in part by HIF-2 [alpha], is also described.
本文描述了抑制HIF-2α的化合物和含有一种或多种所述化合物的组合物以及合成所述化合物的方法。还描述了此类化合物和组合物用于治疗各种各样的疾病、障碍和病症的用途，所述疾病、障碍和病症包括至少部分地由HIF-2α介导的与癌症和免疫有关的病症。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors |
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