Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 [alpha] inhibitors

Described herein are compounds that inhibit HIF-2 [alpha] and compositions containing one or more of the compounds and methods of synthesizing the compounds. The use of such compounds and compositions for the treatment of a wide variety of diseases, disorders and conditions, including cancer and immune related conditions mediated at least in part by HIF-2 [alpha], is also described. 本文描述了抑制HIF-2α的化合物和含有一种或多种所述化合物的组合物以及合成所述化合物的方法。还描述了此类化合物和组合物用于治疗各种各样的疾病、障碍和病症的用途，所述疾病、障碍和病症包括至少部分地由HIF-2α介导的与癌症和免疫有关的病症。