Fully human-derived antagonistic antibody taking connective tissue growth factor as target spot and application of fully human-derived antagonistic antibody

The invention relates to the technical field of gene engineering and protein engineering, in particular to a fully human antagonistic antibody taking a connective tissue growth factor as a target spot and application of the fully human antagonistic antibody. Wherein the fully human antagonistic antibody taking the connective tissue growth factor as the target spot is a single-chain antibody, and the amino acid sequence of the fully human antagonistic antibody is shown as SEQ ID NO: 3. According to the present invention, through the ScFv phage antibody library of rheumatoid arthritis patients, the completely human anti-CTGF monoclonal antibody is screened, the nucleotide sequence and the amino acid sequence of the completely human anti-CTGF monoclonal antibody are respectively determined, and the completely human antagonistic antibody obtained through the method has the specificity of targeting the human connective tissue growth factor. 本发明涉及基因工程和蛋白质工程技术领域，具体涉及一种以结缔组织生长因子为靶点的全人源拮抗抗体及其应用。其中以结缔组织生长因子为靶点的全人源拮抗抗体，