Green synthesis method of 1-alkoxy isoquinoline compound

The invention belongs to the technical field of organic synthesis, and discloses a green synthesis method of a 1-alkoxy isoquinoline compound, which comprises the following steps: carrying out an addition reaction by taking a cyanobenzene compound and alcohol as initial raw materials and an eutectic as a solvent, and then carrying out an intramolecular C-H activation/cyclization reaction with vinylene carbonate under the action of a cobalt catalyst and an additive to obtain the 1-alkoxy isoquinoline compound. And the 1-alkoxy isoquinoline compound is obtained through preparation. The method has the advantages of simple and easily available initial raw materials, low price, high reaction selectivity, high product yield and excellent compatibility of substrate functional groups, the eutectic solvent/cobalt salt catalytic system can be recycled for many times, and the production cost is greatly reduced. 本发明属于有机合成技术领域，公开一种1-烷氧基异喹啉化合物的绿色合成方法，以苯甲腈类化合物和醇为反应的起始原料，以低共熔物为溶剂，发生加成反应，继而在钴催化剂和添加剂作用下与碳酸亚乙烯酯发生分子内C-H活化/环化反应，制