Chloroquine derivative and preparation method thereof

The invention discloses a chloroquine derivative and a preparation method thereof. According to the invention, hydroxychloroquine is taken as an initial raw material, substituted or unsubstituted five-membered and six-membered nitrogen heterocyclic compounds with various biological and pharmaceutical activities are combined with chloroquine with wide pharmacological activity through a simple two-step reaction, and the chloroquine derivative is obtained. The preparation method provided by the invention has the advantages of high target product selectivity, relatively high yield, easiness in separation and purification, easiness in industrial application of a synthesis process and the like, and has good application prospects and potential in the field of drug development. 本发明公开了一种氯喹衍生物及其制备方法。本发明通过以羟基氯喹为初始原料，通过简单的两步反应将具有多种生物、药物活性的取代或未取代的五元、六元氮杂环化合物与同样具有广泛的药理活性的氯喹拼合，得到氯喹衍生物。本发明提供的制备方法具有目标产物选择性高、收率较高，分离纯化容易，合成工艺易于工业应用等优点，在药物开发领域具有良好的应用前景和潜力。