Application of cholesterol regulator as antigen presentation accelerant in hepatitis B treatment

The invention relates to an application of a cholesterol regulator as an antigen presentation promoter in hepatitis B treatment. Researches show that the combination of the cholesterol regulator and the rHBV vaccine can be used for treatment of HBV through a Prime-boost vaccination strategy, and lon...

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Bibliographische Detailangaben
Hauptverfasser: WANG YUCAN, YANG AILU, ZHANG JIAN, ZHAO HUAJUN, HAN QIUJU, HU YIFEI, QIU XUELIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an application of a cholesterol regulator as an antigen presentation promoter in hepatitis B treatment. Researches show that the combination of the cholesterol regulator and the rHBV vaccine can be used for treatment of HBV through a Prime-boost vaccination strategy, and long-term effective virology control is realized. The combination of the cholesterol regulator and the rHBV vaccine is applied to the clinical HBV treatment process, the formation disorder of cholesterol and lipid rafts on dendritic cells caused by chronic HBV infection can be recovered, and the antigen presentation function of the dendritic cells and the cell response and body fluid response of the organism are enhanced, so that the complete removal of HBV is realized. More importantly, the combination of the cholesterol regulator and the rHBV vaccine can induce the body to form long-term immune memory, protect the body and prevent HBV reinfection, and provide a new effective strategy for clinical treatment of chroni