Substituted pyridazine compounds

The present invention addresses the problem of providing a pharmaceutical composition, in particular, a compound suitable for the prevention and/or treatment of inflammatory diseases and/or neurodegenerative diseases. The present inventors have undergone in-depth studies on the exploration of compounds having an NLRP3 inflammasome activation inhibitory effect, and have found that substituted pyridazine compounds have an NLRP3 inflammasome activation inhibitory effect, thereby completing the present invention. This substituted pyridazine compound is expected to be used as a prophylactic and/or therapeutic agent for inflammatory diseases and/or neurodegenerative diseases. 本发明的课题是提供一种医药组合物，特别是适于预防和/或治疗炎症性疾病和/或神经变性疾病的化合物。本发明人对具有NLRP3炎性小体活化抑制作用的化合物的探索进行了深入地研究，发现取代哒嗪化合物具有NLRP3炎性小体活化抑制作用，从而完成本发明。本发明的取代哒嗪化合物可期待作为炎症性疾病和/或神经变性疾病的预防和/或治疗药。