Synthetic method of 3-ethyl-7-(hydroxymethyl)-1, 5-naphthyridine-2 (1H)-ketone

The invention provides a preparation method of 3-ethyl-7-(hydroxymethyl)-1, 5-naphthyridine-2 (1H)-ketone, which comprises the following reaction steps: taking 2-methyl-3-amino-5-bromopyridine as a reactant, and carrying out oxidation, ring closing, esterification, hydrolysis and the like. The 2-methyl-3-amino-5-bromopyridine can also be prepared by taking 5-bromine-2-methyl-3-nitropyridine as a raw material to react with the 5-bromine-2-methyl-3-nitropyridine as a raw material. The method has the advantages of cheap and easily available raw materials, high yield and easy purification, is suitable for industrial large-scale production, and has popularization and application prospects. 本发明提供了一种3-乙基-7-(羟甲基)-1,5-萘啶-2(1H)-酮的制备方法，包以2-甲基-3-氨基-5-溴吡啶为反应物，通过氧化、关环、酯化、水解等反应步骤。2-甲基-3-氨基-5-溴吡啶还可通过5-溴-2-甲基-3-硝基吡啶为原料反应制得。本发明方法所用原料廉价易得，收率高，易纯化，适合工业化放大生产，具有推广应用前景。