Preparation method of calcium phosphate ceramic for drug loading and drug loading method

The invention discloses a preparation method of calcium phosphate ceramic for drug loading and a drug loading method, and the preparation method comprises the following steps: step 1, placing porous calcium phosphate ceramic in a hydrothermal medium formed by a phosphorus-containing organic salt or...

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Hauptverfasser: ZHANG XINGDONG, FENG CONG, XIAO YUMEI, LI XIANGFENG, ZHU XIANGDONG, HE TINGHAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of calcium phosphate ceramic for drug loading and a drug loading method, and the preparation method comprises the following steps: step 1, placing porous calcium phosphate ceramic in a hydrothermal medium formed by a phosphorus-containing organic salt or inorganic salt solution, and after the hydrothermal reaction is sufficient, washing and drying to obtain calcium phosphate ceramic with a hollow tube structure; and step 2, placing the calcium phosphate ceramic with the hollow tube structure obtained in the step 1 in a gel solution, adding a cross-linking agent, vacuumizing and carrying out a gel reaction, and obtaining the required calcium phosphate ceramic after gel formation, the calcium phosphate ceramic with the long-acting antibiotic release function is obtained through specific hydro-thermal treatment, antibiotic adsorption and gel coating, and the calcium phosphate ceramic with the long-acting antibiotic release function not only has the long-acting antibio