Traditional Chinese medicine composition for treating obesity and application thereof

The invention provides a traditional Chinese medicine composition for treating obesity and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 15-20 parts of coptis chinensis, 8-12 parts of cinnamon, 8-14 parts of rhizoma anemarrhenae, 8-12 parts of scutellaria baicalensis, 4-6 parts of radix achyranthis bidentatae, 4-6 parts of poria cocos and 2-4 parts of liquorice. By researching the influence of the traditional Chinese medicine composition on mRNA expression of olanzapine-induced obesity rat central 5-HT synaptic signaling pathway key egg white amino acid hydroxylase 2 (TPH2) and 5-HT transporter (Slc6a4) and mRNA expression of hypothalamic appetite regulation neuropeptide, the result shows that the traditional Chinese medicine composition can reverse olanzapine-induced midseam dorsal nucleus TPH2 and Slc6a4 expression down-regulation, and can be used for treating olanzapine-induced obesity. The mRNA expression of hypothalamic preopioid melanocyte corticoid (POMC