Method for synthesizing 6-trifluoromethyl uracil and intermediate of 6-trifluoromethyl uracil

The invention provides a method for synthesizing 6-trifluoromethyl uracil and an intermediate of the 6-trifluoromethyl uracil. The method comprises the following steps: step 1, reacting an amino compound with a halogenated acetylation reagent under the action of alkali 1 to obtain a compound (I), st...

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Bibliographische Detailangaben
Hauptverfasser: CHEN, BANGI, ZHANG HONGWEI, ZHANG TIANHAO, SHENG GUORONG, SHENG QIUJU, YAO BO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a method for synthesizing 6-trifluoromethyl uracil and an intermediate of the 6-trifluoromethyl uracil. The method comprises the following steps: step 1, reacting an amino compound with a halogenated acetylation reagent under the action of alkali 1 to obtain a compound (I), step 2, reacting the compound (I) obtained in the step 1 with a compound (II) under the action of alkali 2 in a certain solvent to obtain the 6-trifluoromethyl uracil compound, and the reaction formula is as follows: step 1: step 2, r1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or a nitrogen-containing heterocyclic ring; x is halogen; r2 is hydrogen, substituted or non-substituted alkyl; and R3 is substituted or non-substituted alkyl. The method can be applied to preparation of the difenosulam, and has the advantages of simplicity and convenience in operation, safety and easiness in obtaining of raw materials, mild reaction, high yield and suitability for industrial produ