Anti-helicobacter urea and thiourea derivatives of azolones

The invention is concerned with the compounds having the formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydroge...

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Bibliographische Detailangaben
Hauptverfasser: R. A. STOKBROEKX, M. WILLEMS, J. HEERES
Format: Patent
Sprache:eng
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Zusammenfassung:The invention is concerned with the compounds having the formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is C1-4alkyl; C1-4alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C1-4alkyl; Z is C=O or CHOH; and is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7) Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.