Sesterterpene compound as well as synthetic gene cluster and synthetic method thereof

The invention relates to a sesterterpene compound as well as a biosynthetic gene cluster and a synthetic method thereof, the sesteraterin sesterterpene biosynthetic gene cluster aas is obtained from a fungus Alternaria alternata strain through genome mining, the gene cluster comprises a terpene cyclase gene aasA and two cytochrome P450 enzyme genes aasB and aasC, and the two cytochrome P450 enzyme genes aasB and aasC are used for preparing the sesteraterin sesterterpene biosynthetic gene cluster aas, and the sesteraterin sesterterpene biosynthetic gene cluster aas is used for preparing the sesteraterin sesterterpene biosynthetic gene cluster aas and the sesteraterin sesterterpene biosynthetic gene cluster aas. All genes in a gene cluster are expressed through an aspergillus oryzae heterologous expression system, nine sesterone sesterterpene compounds which are novel in structure and have antibacterial activity are obtained in total, the biosynthesis route of the compounds is reported for the first time, an im