Z-configuration allyl amino acid derivative as well as preparation method and application thereof

The invention discloses a Z-configuration allyl amino acid derivative and belongs to the technical field of organic chemical synthesis, the compound has a structure as shown in a formula (I), and the invention also discloses a preparation method of the compound, the preparation method comprises the...

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Hauptverfasser: RAO HANWEN, WANG ZHENHUA, YUAN WEICHENG, QIAN HUILING, ZHANG XUEMAN, YOU YONG, ZHANG YANPING, ZHAO JIANQIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a Z-configuration allyl amino acid derivative and belongs to the technical field of organic chemical synthesis, the compound has a structure as shown in a formula (I), and the invention also discloses a preparation method of the compound, the preparation method comprises the following steps: dissolving alkenyl cyclic ethylene carbonate (II) and azlactone (III) in an organic solvent, and stirring to obtain a mixture; then adding a palladium source and a ligand, stirring and reacting at a certain temperature, and after the reaction is finished, separating and purifying to obtain a product I; the allyl amino acid derivative provided by the invention has a unique Z-configuration, contains a quaternary carbon chiral center, and plays a very important role in pharmaceutical chemical synthesis; meanwhile, the compound can be further synthesized into a new compound with antitumor activity through functional group conversion; the preparation method disclosed by the invention has the advantages