Preparation method of 2-alkyl indan-1-one compound

The invention discloses a preparation method of a 2-alkyl indan-1-one compound, which comprises the following steps: in the presence of a guiding group and a rhodium catalyst, carrying out intramolecular olefin one-carbon insertion non-tension ketone carbon-carbon bond reaction on a raw material com...

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Hauptverfasser: XIA YING, WU XIULI, YE QIAN, HUANG JIANGKUN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of a 2-alkyl indan-1-one compound, which comprises the following steps: in the presence of a guiding group and a rhodium catalyst, carrying out intramolecular olefin one-carbon insertion non-tension ketone carbon-carbon bond reaction on a raw material compound I-0, and treating after the reaction to obtain the 2-alkyl indan-1-one compound. The preparation method of the 2-alkyl indan-1-one compound, disclosed by the invention, is high in selectivity, and is beneficial to improving the conversion rate of reaction and improving the yield of a target product; the purification operation of the 2-alkyl substituted indan-1-one compound is facilitated, and the purity of a target product is improved; the synthesis route is simple and easy to synthesize; the method is simple and easy to operate, mild in condition, free of potential safety hazards and environmental pollution and beneficial to industrial wide popularization and production application. 本发明公开了一种2-烷基茚满-1-酮类化合物的制备