Preparation method of 2-alkyl indan-1-one compound
The invention discloses a preparation method of a 2-alkyl indan-1-one compound, which comprises the following steps: in the presence of a guiding group and a rhodium catalyst, carrying out intramolecular olefin one-carbon insertion non-tension ketone carbon-carbon bond reaction on a raw material com...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a preparation method of a 2-alkyl indan-1-one compound, which comprises the following steps: in the presence of a guiding group and a rhodium catalyst, carrying out intramolecular olefin one-carbon insertion non-tension ketone carbon-carbon bond reaction on a raw material compound I-0, and treating after the reaction to obtain the 2-alkyl indan-1-one compound. The preparation method of the 2-alkyl indan-1-one compound, disclosed by the invention, is high in selectivity, and is beneficial to improving the conversion rate of reaction and improving the yield of a target product; the purification operation of the 2-alkyl substituted indan-1-one compound is facilitated, and the purity of a target product is improved; the synthesis route is simple and easy to synthesize; the method is simple and easy to operate, mild in condition, free of potential safety hazards and environmental pollution and beneficial to industrial wide popularization and production application.
本发明公开了一种2-烷基茚满-1-酮类化合物的制备 |
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