Tacrolimus nano-liposome ophthalmic preparation with biological adhesiveness and preparation method of tacrolimus nano-liposome ophthalmic preparation
The invention relates to a tacrolimus nano-liposome ophthalmic preparation with biological adhesion and a preparation method thereof, the tacrolimus nano-liposome ophthalmic preparation is prepared from tacrolimus nano-liposome and biological adhesion gel, the tacrolimus nano-liposome is prepared by...
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| creator | XUE SONG YANG XUEHUA ZHANG DAIZHOU CUI YAN CHEN QIANQIAN MAO KAIFAN LIU ZHENGPING LI DAWEI |
| description | The invention relates to a tacrolimus nano-liposome ophthalmic preparation with biological adhesion and a preparation method thereof, the tacrolimus nano-liposome ophthalmic preparation is prepared from tacrolimus nano-liposome and biological adhesion gel, the tacrolimus nano-liposome is prepared by adopting a microfluidic injection method, and the biological adhesion gel is prepared by adopting a biological adhesion material. The tacrolimus injection comprises the following components in percentage by weight: 0.05%-2% of tacrolimus, 1%-6% of phospholipid, 0.1%-0.75% of cholesterol, 0.2%-1.6% of an emulsifier, 3%-14% of a bioadhesive material, 0.01% of a preservative, a pH regulator for regulating the pH of the preparation to 6.0-8.0, and the balance of water for injection. The prepared ophthalmic preparation solves the problems of low solubility of tacrolimus and short eye retention time of a common preparation, and has the advantages of controllable particle size, high encapsulation efficiency and easy real |
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The tacrolimus injection comprises the following components in percentage by weight: 0.05%-2% of tacrolimus, 1%-6% of phospholipid, 0.1%-0.75% of cholesterol, 0.2%-1.6% of an emulsifier, 3%-14% of a bioadhesive material, 0.01% of a preservative, a pH regulator for regulating the pH of the preparation to 6.0-8.0, and the balance of water for injection. 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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Tacrolimus nano-liposome ophthalmic preparation with biological adhesiveness and preparation method of tacrolimus nano-liposome ophthalmic preparation |
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