Bridged nucleoside and nucleotide using same

Disclosed are a bridged nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the following formula (I). The bridged nucleoside of the present invention can replace a phosphorothioate-modified nucleic acid, which is concerned to be accumulated in a spe...

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Bibliographische Detailangaben
Hauptverfasser:	INOUE TAKAO, SUGIURA TAKAYA, YOSHIDA NORIYUKI, YAMAGUCHI, TAKUO, KOMINE, TOBIKI, OBIKA SATOSHI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are a bridged nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the following formula (I). The bridged nucleoside of the present invention can replace a phosphorothioate-modified nucleic acid, which is concerned to be accumulated in a specific organ or the like, and has excellent industrial productivity. 本发明公开了桥连型核苷和使用了该核苷的核苷酸。本发明的核苷由以下式(I)表示。本发明的桥连型核苷能够替代存在在特定脏器蓄积等顾虑的硫代磷酸酯修饰核酸，工业上的生产率也优异。