一种洛匹那韦超细微粒制备设备及制备方法

本发明适用于药物化学技术领域，提供了一种洛匹那韦超细微粒制备设备及制备方法；所述洛匹那韦超细微粒制备方法，包括以下步骤：原料混合：将洛匹那韦原料粉末加入到有机溶剂中，超声处理后得到洛匹那韦初始溶液；预热排气：设定结晶装置温度，预热30～50min后排净结晶装置内空气，然后升压稳定至8～14MP；结晶：将初始药物溶液和CO2通入结晶装置，反应结束后以6～8L/min继续通入CO2，0.5～1.5h后卸压，收集洛匹那韦超细微粒。本发明制备过程不会引发药物成分的降解和化学衍生反应，可以保证药物的化学结构保持一致。 The invention is suitable for the technical field of medicinal chemistry, and provides lopinavir ultrafine particle preparation equipment and a preparation method. The preparation method of the lopinavir ultrafine particles comprises the following steps: mixing raw materials: adding lopinavir raw material powder into an organic solvent, and carrying out ultrasonic treatment to obtain a lopinavir initial solution; preheating and exhausting: setting the temperature of the crystallization device, preheating for 30-50 minutes, exhausting air in the crystallization device, and then boosting and stabilizing to 8-14 MP; and crystallization: introducing the initial drug solution and CO2 into a crystallization device, continuously introducing CO2 at the speed of 6-8