Application of alcohol compound 1 in preparation of medicine for treating pulmonary arterial hypertension
The invention belongs to the field of medicines, and relates to a therapeutic drug for pulmonary arterial hypertension, in particular to application of an alcohol compound 1 in pulmonary arterial hypertension treatment. The invention discloses application of an alcohol compound 1 in preparation of a...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention belongs to the field of medicines, and relates to a therapeutic drug for pulmonary arterial hypertension, in particular to application of an alcohol compound 1 in pulmonary arterial hypertension treatment. The invention discloses application of an alcohol compound 1 in preparation of a medicine for treating or preventing pulmonary arterial hypertension, and the alcohol compound 1 is named as 1-5-{[4-(ethylamino) pyrimidine-2-yl] amino}-7, 7-dimethyl-5, 6, 7, 8-tetrahydroquinazoline-2-yl) piperidine-4-alcohol. The alcohol compound 1 can reduce pulmonary vascular remodeling caused by abnormal proliferation of pulmonary artery smooth muscle cells; pulmonary arterial pressure (mPAP) and right ventricular systolic pressure (RVHI) are significantly reduced; the traditional Chinese medicine composition has the effects of reducing serum creatine kinase activity and myocardial cell death, has a myocardial protection effect, and has the effect of improving various clinical symptoms of pulmonary arterial h |
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