Application of CARM1 inhibitor in preparation of tumor ferroptosis inducer

The invention relates to application of a CARM1 inhibitor in preparation of a ferroptosis inducer. The CARM1 inhibitor is used for preparing the ferroptosis inducer and is combined with other anti-tumor drugs, so that the wide drug resistance of the existing anti-tumor drugs can be improved, and par...

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Bibliographische Detailangaben
Hauptverfasser:	CHENG YIMING, SUN SUNG-HO, LIU ZHENFENG, LI XUANYUAN, SU YIJIE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to application of a CARM1 inhibitor in preparation of a ferroptosis inducer. The CARM1 inhibitor is used for preparing the ferroptosis inducer and is combined with other anti-tumor drugs, so that the wide drug resistance of the existing anti-tumor drugs can be improved, and particularly, the anti-tumor effect of the CARM1 inhibitor can be enhanced and the defect of the wide drug resistance of the CARM1 inhibitor can be corrected when the CARM1 inhibitor is combined with sorafenib. 本发明涉及CARM1抑制剂在制备铁死亡诱导剂的应用。本发明将CARM1抑制剂用于制备铁死亡诱导剂并联合其他抗肿瘤药物，可改善已有抗瘤药物广泛的耐药性，特别与索拉非尼联合应用，可增强其抗肿瘤作用、纠正其广泛耐药性的缺陷。