Tricyclic pyridone compound with antiviral activity and application thereof

The invention discloses a tricyclic pyridone compound with a structure as shown in a formula I or a pharmaceutical salt thereof. The compound has anti-coronavirus activity, and has relatively strong inhibitory activity on coronavirus. The invention also discloses application of the tricyclic pyridon...

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Hauptverfasser:	XIAO TONGMEI, SU BINGJIE, SI SHUYI, CHANG SHANSHAN, GAO RONGMEI, CHEN YUCHUAN, YAN BIYING, CHEN MINGHUA, LI YUHUAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a tricyclic pyridone compound with a structure as shown in a formula I or a pharmaceutical salt thereof. The compound has anti-coronavirus activity, and has relatively strong inhibitory activity on coronavirus. The invention also discloses application of the tricyclic pyridone compound shown in the formula I or the pharmaceutical salt thereof in preparation of drugs for treating related diseases caused by coronavirus and/or influenza virus infection. The invention further discloses application of the tricyclic pyridone compound with the structure shown in the formula II or the pharmaceutical salt of the tricyclic pyridone compound in preparation of drugs for treating related diseases caused by coronavirus and/or influenza virus infection, R is selected from H and CH3, and R1 is selected from H and CH3. 本发明公开了结构如式Ⅰ所示的三环吡啶酮类化合物或其药用盐；该化合物具有抗冠状病毒活性，对冠状病毒具有较强的抑制活性。本发明还公开了式Ⅰ所式的三环吡啶酮类化合物或其药用盐在制备治疗冠状病毒和/或流感病毒感染引起的相关疾病药物中的应用。本发明还公开了结构如式Ⅱ所述的三环吡啶酮类化合物或其药用盐在制备治疗冠状病毒和/或流感病毒感染引起的相关疾病药物中的应用，其中，R选自R1选