Crystal form of salt of nitrogen-containing fused heterocyclic compound as well as preparation method and application of crystal form

The invention discloses a crystal form of salt of a nitrogen-containing fused heterocyclic compound as well as a preparation method and application of the crystal form. The crystal form is a crystal form A of fumarate of a nitrogen-containing fused heterocyclic compound as shown in a formula II-b, a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ZHAI XIONG, KE YING, GE HUI, XIA GUANGXIN, WANG QIAN, LOU JIANGSONG
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a crystal form of salt of a nitrogen-containing fused heterocyclic compound as well as a preparation method and application of the crystal form. The crystal form is a crystal form A of fumarate of a nitrogen-containing fused heterocyclic compound as shown in a formula II-b, a crystal form B of fumarate of a nitrogen-containing fused heterocyclic compound as shown in a formula II-b, and a crystal form A of maleate of a nitrogen-containing fused heterocyclic compound as shown in a formula II-a, a crystal form A of succinate of a nitrogen-containing fused heterocyclic compound as shown in formulas II-c or a crystal form A of hydrochloride of the nitrogen-containing fused heterocyclic compound as shown in formulas II-d. The crystal form has low hygroscopicity and has good stability and pharmacokinetic properties compared with free alkali. . 本发明公开了一种含氮稠杂环化合物的盐的晶型及其制备方法和应用。该晶型为如式II-b所示的含氮稠杂环化合物的富马酸盐的晶型A、如式II-b所示的含氮稠杂环化合物的富马酸盐的晶型B、如式II-a所示的含氮稠杂环化合物的马来酸盐的晶型A、如式II-c所示的含氮稠杂环化合物的琥珀酸盐的晶型A或如式II-d所示