Norovirus specific CD8 + T cell epitope peptide and application thereof
The invention belongs to the technical field of gene engineering and protein engineering, and particularly relates to a norovirus specific CD8 + T cell epitope peptide and application thereof. Studies are developed around capsid protein specific CD8 + T cells of NV viruses, peptide libraries and pep...
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| creator | CHEN YING WU CHAO ZHANG JIN WANG QINJIN LI BIN YE KAIJIE NING JIE HE TAOJUN DENG YILIN |
| description | The invention belongs to the technical field of gene engineering and protein engineering, and particularly relates to a norovirus specific CD8 + T cell epitope peptide and application thereof. Studies are developed around capsid protein specific CD8 + T cells of NV viruses, peptide libraries and peptide fragments of capsid protein immunodominance response are sequentially screened out through an in-vitro detection method, then an in-vitro amplification culture system of the NV immunodominance peptide specific CD8 + T cells is constructed on the basis of immunodominance peptides, and the NV immunodominance peptide specific CD8 + T cells are obtained. The specific CD8 + T cells of the dominant peptides of the VP1-P23, the VP2-P16 and the VP2-P26 are successfully cultured. And on the basis of the dominant 18 peptide, the epitopes of the core oligopeptides are sequentially identified. The norovirus specific CD8 + T cell epitope peptide disclosed by the invention can be used for diagnosing NV infection, has a prot |
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Studies are developed around capsid protein specific CD8 + T cells of NV viruses, peptide libraries and peptide fragments of capsid protein immunodominance response are sequentially screened out through an in-vitro detection method, then an in-vitro amplification culture system of the NV immunodominance peptide specific CD8 + T cells is constructed on the basis of immunodominance peptides, and the NV immunodominance peptide specific CD8 + T cells are obtained. The specific CD8 + T cells of the dominant peptides of the VP1-P23, the VP2-P16 and the VP2-P26 are successfully cultured. And on the basis of the dominant 18 peptide, the epitopes of the core oligopeptides are sequentially identified. 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | Norovirus specific CD8 + T cell epitope peptide and application thereof |
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