Norovirus specific CD8 + T cell epitope peptide and application thereof

The invention belongs to the technical field of gene engineering and protein engineering, and particularly relates to a norovirus specific CD8 + T cell epitope peptide and application thereof. Studies are developed around capsid protein specific CD8 + T cells of NV viruses, peptide libraries and peptide fragments of capsid protein immunodominance response are sequentially screened out through an in-vitro detection method, then an in-vitro amplification culture system of the NV immunodominance peptide specific CD8 + T cells is constructed on the basis of immunodominance peptides, and the NV immunodominance peptide specific CD8 + T cells are obtained. The specific CD8 + T cells of the dominant peptides of the VP1-P23, the VP2-P16 and the VP2-P26 are successfully cultured. And on the basis of the dominant 18 peptide, the epitopes of the core oligopeptides are sequentially identified. The norovirus specific CD8 + T cell epitope peptide disclosed by the invention can be used for diagnosing NV infection, has a prot