Compound as well as preparation method, pharmaceutical composition and application thereof

The invention provides a compound as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. The compound provided by the invention can achieve the purpose of preventing and/or treating tumors by inhibiting the activity of STAT3, and meanwhile, the compound provided by the invention can improve the immunocompetence of an organism on tumors so as to enhance the anti-tumor activity; the purpose of preventing and/or treating tumors can be achieved by administering an effective amount of the compound to a patient requiring tumor prevention and/or treatment. Results of the embodiment show that the compound provided by the invention has antitumor pharmacological activity. 本发明提供了一种化合物及其制备方法和药物组合物及应用，属于药物技术领域。本发明提供的化合物能够通过抑制STAT3活性达到预防和/或治疗肿瘤目的，同时本发明提供的化合物能够提高机体对肿瘤的免疫能力而增强抗肿瘤活性，可以通过向需要肿瘤预防和/或治疗的患者给予有效量的化合物来达到预防和/或治疗肿瘤的目的。实施例的结果显示，本发明提供的化合物具有抗肿瘤药理活性。