Quinazoline benzamide compound as well as derivative, pharmaceutical composition and application thereof

The invention provides a quinazoline benzamide compound as well as a derivative, a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The quinazoline benzamide compound provided by the invention has a structure as shown in a formula I, R is-NHR1 or azacyclo, and R1 in the-NHR1 comprises any one of the following structures: the IC50 of the quinazoline benzamide compound to JNK1 is as low as 2.8 nM, the IC50 of the quinazoline benzamide compound to JNK2 is as low as 4.6 nM, and the IC50 of the quinazoline benzamide compound to JNK3 is as low as 5.1 nM, so that the quinazoline benzamide compound has very high JNK inhibitory activity, can improve the ability of an immune system, and can be used for preparing a medicine for treating the immune system. The compound has high anti-tumor pharmacological activity, and has good application prospects in treatment and/or prevention of respiratory system diseases, fatty liver, hepatic fibrosis, chronic inflammatory diseases