Application of naphthoquine phosphate in preparation of medicine for treating autoimmune diseases

The invention discloses application of naphthoquine phosphate in preparation of a medicine for treating autoimmune diseases. A mouse rheumatoid arthritis model proves that the naphthoquine phosphate intragastric administration can obviously improve the symptoms of joint redness, swelling, deformatio...

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Hauptverfasser: HE SHIJUN, ZHAO LIMIN, DING XIYING, ZHANG HONGYING, ZUO JIANPING, MAO GUANXING, WANG XUE, XING ZHIGANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of naphthoquine phosphate in preparation of a medicine for treating autoimmune diseases. A mouse rheumatoid arthritis model proves that the naphthoquine phosphate intragastric administration can obviously improve the symptoms of joint redness, swelling, deformation and the like and reduce the antigen-specific antibody level. A mouse systemic lupus erythematosus model proves that the levels of double-stranded DNA antibodies and antinuclear antibodies can be remarkably reduced by intragastric administration of naphthoquine. Pharmacological studies prove that naphthoquine phosphate has ideal immunosuppressive activity and can be used for preparing drugs for treating autoimmune diseases. The invention further provides a pharmaceutical application of naphthoquine phosphate in treatment and adjuvant treatment of rheumatoid arthritis and systemic lupus erythematosus. The medicine disclosed by the invention is a pharmaceutical composition consisting of an effective amount of naphth