Diagnostic and therapeutic methods for treatment of hematologic cancers

Disclosed herein are diagnostic and therapeutic methods and related compositions for the treatment of hematological cancers, including multiple myeloma (MM). In particular, the present invention relates to diagnostic and therapeutic methods comprising treatments for the treatment of hematological cancers (e.g., multiple myeloma (MM), e.g., recurrent or refractory MM), e.g., a PD-L1 axis binding antagonist (e.g., an anti-PD-L1 antibody, e.g., altezumab) and an anti-CD38 antibody (e.g., an anti-CD38 antagonist antibody, e.g., dalmemumab). 本文公开了用于治疗包括多发性骨髓瘤(MM)在内的血液癌症的诊断和治疗方法以及相关的组合物。特别地，本发明涉及包含用于治疗血液癌症(例如，多发性骨髓瘤(MM)，例如复发性或难治性MM)的PD-L1轴结合拮抗剂(例如，抗PD-L1抗体，例如阿特珠单抗)和抗CD38抗体(例如，抗CD38拮抗剂抗体，例如达雷木单抗)的治疗的诊断和治疗方法。