OTUB1 gene and application of detection reagent and inhibitor thereof

The invention belongs to the technical field of biological medicines, and particularly relates to an OTUB1 gene and application of a detection reagent and an inhibitor thereof. The invention proves that the expression of the OTUB1 gene in gastric cancer is increased and is related to low survival ra...

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Hauptverfasser:	JI ZHIPENG, ZANG YIFENG, ZHOU YAN, WANG DEHAI, LIU ZIPING, JIANG RIXIA, WANG TIANSHI, LI QUANHUI, DING YINLU, WANG YUAN, LIU BINGTIAN, MI YUSHUAI, ZHU JIAN, YAN CHENG, GAO ZHUANGLEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of biological medicines, and particularly relates to an OTUB1 gene and application of a detection reagent and an inhibitor thereof. The invention proves that the expression of the OTUB1 gene in gastric cancer is increased and is related to low survival rate. By detecting the expression level of the OTUB1 gene in a subject, whether the subject suffers from the gastric cancer or not and the risk of suffering from the gastric cancer can be judged. The OTUB1 consumption can inhibit the progress of gastric cancer in vivo and in vitro, so that the treatment of gastric cancer by taking the OTUB1 gene as the target spot has better feasibility and generalization performance. 本发明属于生物医药技术领域，具体涉及OTUB1基因、其检测试剂和抑制剂的应用。本发明证实了OTUB1基因在胃癌中表达升高，并与低生存率相关。通过检测受试者中所述OTUB1基因的表达水平，可以判断受试者是否患有胃癌以及患胃癌的风险。OTUB1消耗可抑制体内外胃癌的进展，由此可见，以OTUB1基因作为靶点进行胃癌的治疗具有较好的可行性及推广性。