Bispecific factor VIII mimetic antibodies

Bispecific factor VIII mimetic antibodies

The present invention relates to bispecific antibodies capable of binding to coagulation factor IX (FIX) and/or activated form factor IXa (FIXa) thereof and factor X (FX) and/or activated form factor Xa (FXa) thereof and promoting activation of FIXa on FX, and methods and compositions for treating s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LAMBERTH KARL, RODER GEORG, HANSEN BJARNE G, LORENTZEN, NILS, LUND JOHN, GRAYSON, PETER, J
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to bispecific antibodies capable of binding to coagulation factor IX (FIX) and/or activated form factor IXa (FIXa) thereof and factor X (FX) and/or activated form factor Xa (FXa) thereof and promoting activation of FIXa on FX, and methods and compositions for treating subjects suffering from coagulation diseases such as hemophilia A with or without inhibitors. 本发明涉及能够结合凝血因子IX(FIX)和/或其活化形式因子IXa(FIXa)以及因子X(FX)和/或其活化形式因子Xa(FXa)并促进FIXa对FX的激活的双特异性抗体，以及用于治疗罹患诸如具有或不具有抑制物的A型血友病等凝血病的受试者的方法和组合物。