Compositions and methods comprising combination of anti-CD47 antibody and tumor-targeting antibody

The present disclosure provides compositions and methods comprising a first antibody comprising a fully human anti-CD47 antibody and a second antibody comprising an Fc moiety that binds to an Fc gamma receptor on an effector cell. In various embodiments, the anti-CD47 antibodies used in the methods and compositions exhibit low levels of binding to red blood cells and do not induce blood clotting even at high concentrations of antibodies. In some embodiments, the second antibody comprises a tumor targeting antibody, and the tumor targeting antibody comprises an antibody which binds to a CD20 antigen, a PD-L1 antigen, a CD38 antigen or a SLAMF7 antigen. The combination of the fully human anti-CD47 antibody and the second antibody can reduce a cancer burden on the subject. 本公开提供了组合物和方法，所述组合物包含第一抗体和第二抗体，所述第一抗体包括完全人抗CD47抗体，所述第二抗体包含与效应细胞上的Fcγ受体结合的Fc部分。在各个实施方式中，所述方法和所述组合物中使用的所述抗CD47抗体表现出与红细胞的低水平结合并且即使在高浓度的抗体下也不诱导血凝。在一些实施方式中，所述第二抗体包括肿瘤靶向抗体，所述肿瘤靶向抗体包括与CD20、PD-L1、CD38或SLAMF7抗原结合的抗体。所述完全人抗CD47抗体和所述第二抗体的组合可以减少所述受试者的癌症负担。