Nucleic acid or protein loaded pulmonary surfactant particles for inhalation delivery and method of making same

A complex in which a protein or nucleic acid binds to a liposome prepared from a pulmonary surfactant can be selectively delivered to the lung while maintaining its original form and function without compromising the structure of the protein or nucleic acid when administered in vivo. In addition, the complex effectively fuses with a pulmonary surfactant membrane present in pulmonary alveoli, thereby effectively delivering a bound protein or nucleic acid (gene) to surrounding cells, and has low toxicity and excellent structural stability. 一种当体内施用时可以被选择性地递送至肺并同时保持其原始形式和功能而不损害蛋白质或核酸的结构的复合物，在该复合物中，蛋白质或核酸与由肺表面活性物质制备的脂质体结合。另外，该复合物与肺泡中存在的肺表面活性物质膜有效融合，从而将结合的蛋白质或核酸(基因)有效地递送至周围细胞，并且具有低毒性和优异的结构稳定性。