Preparation method of 2-oxoalkyl-9H-pyrrolo [1, 2-a] indole-9-ketone compound

The invention relates to a preparation method of a 2-oxoalkyl-9H-pyrrolo [1, 2-a] indole-9-ketone compound, which comprises the following steps of: uniformly mixing an N-propargyl indole compound, an ether compound, a catalyst, an oxidant, a photocatalyst and a solvent in sequence, reacting for 34 hours at 80 DEG C under blue light, and obtaining reaction liquid after the reaction is complete; the reaction liquid is sequentially subjected to conventional drying, concentration and column chromatography separation, and then the 2-oxoalkyl-9H-pyrrolo [1, 2-a] indole-9-ketone compound is obtained. The method is simple and low in cost, large-scale production can be achieved, and the method has good industrial application prospects in the aspect of synthesis of bioactive compounds and drugs containing the indolo [1, 2-a] indole skeleton. 本发明涉及一种2-氧代烷基-9H-吡咯并[1,2-a]吲哚-9-酮类化合物的制备方法，该方法是指依次N-炔丙基吲哚类化合物、醚类化合物、催化剂、氧化剂、光催化剂和溶剂混合均匀，在蓝光下，80℃反应34小时，反应完全后得反应液；该反应液依次经常规干燥、浓缩、柱层析分离后，即得2-氧代烷基-9H-吡咯并[1,2-a]吲哚-9-酮类化合物。本发明方法简单，成本低廉