Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof
The invention belongs to the technical field of medicinal chemistry, and discloses a dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and a preparation method of the dicationic quaternary ammonium salt antibacterial peptide simulant. The compound has the...
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| creator | HATAKAMI TAKASHI SHEN BOYUAN CHEN SHENGCONG MAXWELL LI WEN LI SEN ZHANG EN GAO CHEN YAN DACHAO WANG MENG |
| description | The invention belongs to the technical field of medicinal chemistry, and discloses a dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and a preparation method of the dicationic quaternary ammonium salt antibacterial peptide simulant. The compound has the following structural general formulas I and II. The antibacterial peptide simulant disclosed by the invention has excellent antibacterial activity and shows good activity on gram-positive bacteria and gram-negative bacteria. The MIC value (minimum inhibitory concentration) of a part of the compounds to four standard bacteria including staphylococcus aureus, escherichia coli, enterococcus faecalis and stenotrophomonas maltophilia is 0.5-4 [mu] g/mL. The HC50 (half hemolytic concentration) result shows that the compound has lower hemolytic toxicity and higher selectivity.
本发明属于药物化学技术领域，公开了具有抗菌活性的双阳离子季铵盐抗菌肽模拟物及其制备方法。该化合物具有如下结构通式I和Ⅱ：本发明所述抗菌肽模拟物具有优异的抗菌活性，对革兰氏阳性菌，革兰氏阴性菌均表现出很好的活性。部分化合物对金黄色葡萄球菌，大肠杆菌，粪肠球菌和嗜麦芽窄食单胞菌四种标准细菌的MI |
| format | Patent |
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本发明属于药物化学技术领域，公开了具有抗菌活性的双阳离子季铵盐抗菌肽模拟物及其制备方法。该化合物具有如下结构通式I和Ⅱ：本发明所述抗菌肽模拟物具有优异的抗菌活性，对革兰氏阳性菌，革兰氏阴性菌均表现出很好的活性。部分化合物对金黄色葡萄球菌，大肠杆菌，粪肠球菌和嗜麦芽窄食单胞菌四种标准细菌的MI</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220913&DB=EPODOC&CC=CN&NR=115043740A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220913&DB=EPODOC&CC=CN&NR=115043740A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HATAKAMI TAKASHI</creatorcontrib><creatorcontrib>SHEN BOYUAN</creatorcontrib><creatorcontrib>CHEN SHENGCONG</creatorcontrib><creatorcontrib>MAXWELL</creatorcontrib><creatorcontrib>LI WEN</creatorcontrib><creatorcontrib>LI SEN</creatorcontrib><creatorcontrib>ZHANG EN</creatorcontrib><creatorcontrib>GAO CHEN</creatorcontrib><creatorcontrib>YAN DACHAO</creatorcontrib><creatorcontrib>WANG MENG</creatorcontrib><title>Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof</title><description>The invention belongs to the technical field of medicinal chemistry, and discloses a dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and a preparation method of the dicationic quaternary ammonium salt antibacterial peptide simulant. The compound has the following structural general formulas I and II. The antibacterial peptide simulant disclosed by the invention has excellent antibacterial activity and shows good activity on gram-positive bacteria and gram-negative bacteria. The MIC value (minimum inhibitory concentration) of a part of the compounds to four standard bacteria including staphylococcus aureus, escherichia coli, enterococcus faecalis and stenotrophomonas maltophilia is 0.5-4 [mu] g/mL. The HC50 (half hemolytic concentration) result shows that the compound has lower hemolytic toxicity and higher selectivity.
本发明属于药物化学技术领域，公开了具有抗菌活性的双阳离子季铵盐抗菌肽模拟物及其制备方法。该化合物具有如下结构通式I和Ⅱ：本发明所述抗菌肽模拟物具有优异的抗菌活性，对革兰氏阳性菌，革兰氏阴性菌均表现出很好的活性。部分化合物对金黄色葡萄球菌，大肠杆菌，粪肠球菌和嗜麦芽窄食单胞菌四种标准细菌的MI</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjb0KwkAQhNNYiPoO6wMICYlYh6hYWdmH9bIhC_fn3Z5i4bt7iJWV1QzzDTPz4rVnhcLOsoJbQqFgMTwBjclRMhBRC6AVvqLKkFGDJy88EEQ2SWcED5bpp5MN31nykB3AB_IYPi9gSCY3gEwUyI3LYjaijrT66qJYHw-X7rQh73qKHhVZkr47V9W2bOpdU7b1P503Q1lJvQ</recordid><startdate>20220913</startdate><enddate>20220913</enddate><creator>HATAKAMI TAKASHI</creator><creator>SHEN BOYUAN</creator><creator>CHEN SHENGCONG</creator><creator>MAXWELL</creator><creator>LI WEN</creator><creator>LI SEN</creator><creator>ZHANG EN</creator><creator>GAO CHEN</creator><creator>YAN DACHAO</creator><creator>WANG MENG</creator><scope>EVB</scope></search><sort><creationdate>20220913</creationdate><title>Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof</title><author>HATAKAMI TAKASHI ; SHEN BOYUAN ; CHEN SHENGCONG ; MAXWELL ; LI WEN ; LI SEN ; ZHANG EN ; GAO CHEN ; YAN DACHAO ; WANG MENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115043740A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HATAKAMI TAKASHI</creatorcontrib><creatorcontrib>SHEN BOYUAN</creatorcontrib><creatorcontrib>CHEN SHENGCONG</creatorcontrib><creatorcontrib>MAXWELL</creatorcontrib><creatorcontrib>LI WEN</creatorcontrib><creatorcontrib>LI SEN</creatorcontrib><creatorcontrib>ZHANG EN</creatorcontrib><creatorcontrib>GAO CHEN</creatorcontrib><creatorcontrib>YAN DACHAO</creatorcontrib><creatorcontrib>WANG MENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HATAKAMI TAKASHI</au><au>SHEN BOYUAN</au><au>CHEN SHENGCONG</au><au>MAXWELL</au><au>LI WEN</au><au>LI SEN</au><au>ZHANG EN</au><au>GAO CHEN</au><au>YAN DACHAO</au><au>WANG MENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof</title><date>2022-09-13</date><risdate>2022</risdate><abstract>The invention belongs to the technical field of medicinal chemistry, and discloses a dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and a preparation method of the dicationic quaternary ammonium salt antibacterial peptide simulant. The compound has the following structural general formulas I and II. The antibacterial peptide simulant disclosed by the invention has excellent antibacterial activity and shows good activity on gram-positive bacteria and gram-negative bacteria. The MIC value (minimum inhibitory concentration) of a part of the compounds to four standard bacteria including staphylococcus aureus, escherichia coli, enterococcus faecalis and stenotrophomonas maltophilia is 0.5-4 [mu] g/mL. The HC50 (half hemolytic concentration) result shows that the compound has lower hemolytic toxicity and higher selectivity.
本发明属于药物化学技术领域，公开了具有抗菌活性的双阳离子季铵盐抗菌肽模拟物及其制备方法。该化合物具有如下结构通式I和Ⅱ：本发明所述抗菌肽模拟物具有优异的抗菌活性，对革兰氏阳性菌，革兰氏阴性菌均表现出很好的活性。部分化合物对金黄色葡萄球菌，大肠杆菌，粪肠球菌和嗜麦芽窄食单胞菌四种标准细菌的MI</abstract><oa>free_for_read</oa></addata></record> |
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| title | Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof |
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