Dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and preparation method thereof

The invention belongs to the technical field of medicinal chemistry, and discloses a dicationic quaternary ammonium salt antibacterial peptide simulant with antibacterial activity and a preparation method of the dicationic quaternary ammonium salt antibacterial peptide simulant. The compound has the following structural general formulas I and II. The antibacterial peptide simulant disclosed by the invention has excellent antibacterial activity and shows good activity on gram-positive bacteria and gram-negative bacteria. The MIC value (minimum inhibitory concentration) of a part of the compounds to four standard bacteria including staphylococcus aureus, escherichia coli, enterococcus faecalis and stenotrophomonas maltophilia is 0.5-4 [mu] g/mL. The HC50 (half hemolytic concentration) result shows that the compound has lower hemolytic toxicity and higher selectivity. 本发明属于药物化学技术领域，公开了具有抗菌活性的双阳离子季铵盐抗菌肽模拟物及其制备方法。该化合物具有如下结构通式I和Ⅱ：本发明所述抗菌肽模拟物具有优异的抗菌活性，对革兰氏阳性菌，革兰氏阴性菌均表现出很好的活性。部分化合物对金黄色葡萄球菌，大肠杆菌，粪肠球菌和嗜麦芽窄食单胞菌四种标准细菌的MI