Compound preparation of potassium-competitive acid blocker and acetylsalicylic acid and preparation method thereof

The invention provides a compound preparation of a potassium-competitive acid blocker and acetylsalicylic acid and a preparation method of the compound preparation. Specifically, the double-layer tablet comprises a first layer tablet and a second layer tablet, the first layer tablet contains 5-(2-fluorophenyl)-N-methyl-1-(3-pyridylsulfonyl)-1H-pyrrole-3-methylamine-L-pyroglutamic acid serving as a first active ingredient and a pharmaceutically acceptable carrier, and the second layer tablet contains a pharmaceutically acceptable carrier and a pharmaceutically acceptable carrier serving as a second active ingredient. And a second layer tablet containing acetylsalicylic acid as a second active ingredient and a pharmaceutically acceptable carrier. The compound preparation disclosed by the invention can control the drug release rate and obviously reduce the gastrointestinal tract side effects of acetylsalicylic acid. 本发明提供了一种钾离子竞争性酸阻滞剂和乙酰水杨酸的复方制剂及其制备方法。具体地，所述双层片剂包括：第一层片，所述第一层片含有作为第一活性成分的5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基