Polyethylene glycol derivative capable of targeting hepatocytes and preparation method thereof

The invention discloses a polyethylene glycol derivative capable of targeting hepatocytes and a preparation method of the polyethylene glycol derivative, and the preparation method comprises the following steps: carrying out chemical modification on double-terminal hydroxyl groups of polyethylene glycol to obtain double-carboxyl polyethylene glycol or double-amino polyethylene glycol; connecting a small molecule compound containing a catechol group to the dicarboxyl polyethylene glycol or the diamino polyethylene glycol through an amido bond to obtain catechol carboxyl/amino polyethylene glycol; and connecting a small molecule compound containing an ethoxyphenyl group to the catechol carboxyl/amino polyethylene glycol through an amido bond to generate the polyethylene glycol derivative. According to the invention, the polyethylene glycol is connected with the small molecule compound containing the catechol group and the small molecule compound containing the ethoxyphenyl group through amido bonds, the synthes