2-trifluoromethyl-3-iodine-indole compound and preparation method thereof

The invention discloses a 2-trifluoromethyl-3-iodine-indole compound and a synthesis method thereof, the structural formula of the compound is shown in the specification, in the formula, R1 is hydrogen, methyl, methoxyl, fluorine, bromine, chlorine and iodine; r2 is hydrogen, 2-(trimethylsilyl) ethoxymethyl, methyl, benzyl or n-butyl. According to the invention, indole is used as a raw material, potassium iodide is used as an iodine source, 1-(trifluoromethyl)-1, 2-benzioyl-3 (1H)-ketone is used as a trifluoromethyl source, and under the action of copper nitrate, a series of 2-trifluoromethyl-3-iodoindole compounds are efficiently constructed. The method has the advantages of simple and easily available raw materials, simple reaction operation, mild conditions, environmental friendliness and the like. The 2-trifluoromethyl-3-iodoindole compound synthesized by the method disclosed by the invention has a wide application prospect in the related fields of organic synthesis, medicinal chemistry and the like. 本发明公