Gold nanocluster as well as preparation method and application thereof

The invention discloses a gold nanocluster and a preparation method and application thereof. The gold nanocluster is modified with ligands, and the ligands comprise a sulfydryl-containing negative electricity ligand and a sulfydryl-containing zwitterionic ligand. According to the gold nano-cluster disclosed by the invention, the effect of passive accumulation in lymph nodes is achieved by regulating and controlling the types of ligands on the surface of the gold nano-cluster, and high-contrast fluorescence radiography of the lymph nodes and diagnosis of cancer lymphatic metastasis are realized by virtue of near-infrared fluorescence of the gold nano-cluster. 本发明公开了一种金纳米簇及其制备方法与应用。所述金纳米簇上修饰有配体，所述配体包括含巯基的负电配体和含巯基的两性离子配体。本发明中的金纳米簇，通过调控金纳米簇表面配体的种类，从而使其达到在淋巴结被动累积的效果，借助其本身的近红外荧光实现淋巴结的高对比度荧光造影以及癌症淋巴转移的诊断。