Cefdinir granules and preparation method thereof

The invention discloses a cefdinir granule and a preparation method thereof. The cefdinir granule comprises the following components in parts by weight: 40-100 parts of cefdinir; 20-50 parts of sucrose fatty acid ester; 350 to 400 parts of a filling agent; 16 to 40 parts of a disintegrating agent; 1...

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Bibliographische Detailangaben
Hauptverfasser: ZHAO YANCHUN, CHEN SHAOBO, WU HUANLING, MA JUNLE, CHEN CAIHUAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a cefdinir granule and a preparation method thereof. The cefdinir granule comprises the following components in parts by weight: 40-100 parts of cefdinir; 20-50 parts of sucrose fatty acid ester; 350 to 400 parts of a filling agent; 16 to 40 parts of a disintegrating agent; 1-5 parts of a lubricant; and 0.5 to 2.5 parts of a flavoring agent. The sucrose fatty acid ester and the cefdinir are subjected to powder coating, the raw materials can be better included, the stability and the dissolution rate of the cefdinir are increased, meanwhile, the sucrose fatty acid ester can promote dissolution of the raw materials, absorption of the cefdinir is accelerated, and the medicine effect is more remarkable. The cefdinir is matched with the disintegrating agent, the filling agent and the lubricating agent, so that the drug release is rapid. The prepared cefdinir granule is subjected to an influence factor test, an acceleration test and a long-term test, and results show that during the accelerat