Nucleotide probes

Compounds useful as nucleic acid probes are disclosed. In certain embodiments, the compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, where M, L1a, L2, L8, L1b, L3, L5, L6, L7, L4, R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, m, n, q, and w are as defined herein. Methods...

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Hauptverfasser: DOMINGUEZ MARK, MATRAY TRACY, KUANG ERIC
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Compounds useful as nucleic acid probes are disclosed. In certain embodiments, the compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, where M, L1a, L2, L8, L1b, L3, L5, L6, L7, L4, R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, m, n, q, and w are as defined herein. Methods related to the preparation and use of such compounds are also provided. 公开了可用作核酸探针的化合物。在某些实施方案中,所述化合物具有以下结构(I):或其立体异构体、互变异构体或盐,其中M、L1a、L2、L8、L1b、L3、L5、L6、L7、L4、R1、R2、R3、R4、R5、Ra、Rb、Rc、Rd、m、n、q和w如本文中定义。还提供了与这样的化合物的制备和用途有关的方法。