Dihydrocyclopenta-isoquinoline sulfonamide derivatives

The present invention relates to dihydrocyclopenta-isoquinoline derivatives of formula (I), to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of disorders caused by IgE (e.g., allergic reactions, non-allergic mastocyte reactions or c...

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Bibliographische Detailangaben
Hauptverfasser:	HASLETT GREGORY WILLIAM, DEMAUDE THIERRY, LALLEMAND BENOIT, MONK, NICO, J., T, NORMAN TIMOTHY JOHN, CONNELLY RICKY LEE, ZHU ZHAONING, RAMPALAKOS KONSTANTINOS, FRANKLIN RICHARD JEREMY, MADAN JANIS, SUGANSHAN SURESH, HERR JAMES P, ROWLEY, JAMES, H, TRANI GIORGIO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to dihydrocyclopenta-isoquinoline derivatives of formula (I), to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of disorders caused by IgE (e.g., allergic reactions, non-allergic mastocyte reactions or certain autoimmune reactions), in particular disorders caused by the interaction of IgE with the Fc [epsilon] RI receptor. 本发明涉及式(I)的二氢环戊二烯并异喹啉衍生物，用于制备其的方法、含有其的药物组合物以及其在治疗由IgE引起的障碍(例如过敏反应、非过敏性肥大细胞反应或某些自身免疫反应)，特别是由IgE与FcεRI受体相互作用引起的障碍中的用途。