Preparation method of deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier
The invention discloses a preparation method of a deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier. The method comprises the following steps: preparing a camptothecin prodrug monomer with a trimer structure; preparing acid responsive removable polyethylene glycol w...
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| creator | MA CHAO YIN JUN YAN JINHAO YANG GUANGWEI |
| description | The invention discloses a preparation method of a deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier. The method comprises the following steps: preparing a camptothecin prodrug monomer with a trimer structure; preparing acid responsive removable polyethylene glycol with double bonds; preparing a poly prodrug with dual responsiveness and high drug loading capacity; and preparation of the deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier: self-assembling the prepared dual-responsiveness high-drug-loading-capacity poly-prodrug in deionized water to obtain the deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier. The drug loading capacity of the camptothecin drug is greatly improved, in addition, due to the dual responsiveness, controllable release of the camptothecin drug is achieved, the size becomes small after a polyethylene glycol chain is removed, then the combining capacity of the nano-carrier and cells is imp |
| format | Patent |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Preparation method of deformable dual-responsiveness high-drug-loading-capacity poly-prodrug nano-carrier |
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